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10.1155/2021/9253281 185 ZhangX.LiY.YangP.LiuX.LuL.ChenY.et al (2020)

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CytC is subsequently released into the cytoplasm, where it binds to apoptosis-related factor 1(Apaf-1), promoting the formation of apoptotic bodies by binding with caspase-9

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131,132 In a clinical trial, a daily caffeine dose of 100 mg was shown to reduce "freezing." However, it appeared the subjects developed a tolerance after a few months